Biliverdin reductase A

BLVRA

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2H63

Identifiers

BLVRA, BLVR, BVR, BVRA, biliverdin reductase A

External IDs

Gene ontology
Molecular function	• protein binding • metal ion binding • zinc ion binding • oxidoreductase activity • biliverdin reductase activity
Cellular component	• extracellular exosome • cytosol • cytoplasm
Biological process	• heme catabolic process • oxidation-reduction process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


644


109778


ENSG00000106605


ENSMUSG00000001999


P53004


Q9CY64

RefSeq (mRNA)


NM_000712 NM_001253823


NM_026678

RefSeq (protein)


NP_000703.2 NP_001240752.1


NP_080954.4

Location (UCSC)

PubMed search

^[1]

^[2]

Biliverdin reductase A is a protein that in humans is encoded by the BLVRA gene.^[3]

Function

The protein encoded by this gene belongs to the biliverdin reductase family, members of which catalyze the conversion of biliverdin to bilirubin in the presence of NADPH or NADH.^[3]

Mutations in this gene are associated with hyperbiliverdinemia.^[3]

Oxidoreductases: CH–CH oxidoreductases (EC 1.3)

1.3.1: NAD/NADP acceptor	Enoyl-acyl carrier protein reductase/Enoyl ACP reductase 7-Dehydrocholesterol reductase Biliverdin reductase 2,4 Dienoyl-CoA reductase Dihydroxymethyloxo-tetrahydroquinoline dehydrogenase

1.3.3: Oxygen acceptor	Dihydroorotate dehydrogenase Coproporphyrinogen III oxidase Protoporphyrinogen oxidase Bilirubin oxidase Acyl-CoA oxidase Dihydrouracil oxidase Tetrahydroberberine oxidase Secologanin synthase Tryptophan alpha,beta-oxidase Pyrroloquinoline-quinone synthase L-galactonolactone oxidase

1.3.5: Quinone	Succinate dehydrogenase SDHA SDHB SDHC SDHD

1.3.99: Other acceptors	Fumarate reductase Butyryl-CoA dehydrogenase Acyl CoA dehydrogenase ACADSB ACADS 5α-reductase SRD5A1 SRD5A2 SRD5A3 Glutaryl-CoA dehydrogenase Isovaleryl coenzyme A dehydrogenase 3-oxo-5beta-steroid 4-dehydrogenase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.