Dihydrokainic acid

Dihydrokainic acid
Names

IUPAC name (3S,4R)-3-(Carboxymethyl)-4-isopropyl-L-proline
Other names Dihydrokainate; DHK
Identifiers
CAS Number	52497-36-6
3D model (Jmol)	Interactive image
ChemSpider	97018
InChI InChI=1S/C10H17NO4/c1-5(2)7-4-11-9(10(14)15)6(7)3-8(12)13/h5-7,9,11H,3-4H2,1-2H3,(H,12,13)(H,14,15)/t6-,7+,9-/m0/s1 Key: JQPDCKOQOOQUSC-OOZYFLPDSA-N
SMILES CC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
Properties
Chemical formula	C₁₀H₁₇NO₄
Molar mass	215.25 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Dihydrokainic acid is an organic compound that contains two carboxylic acid functional groups, making it a dicarboxylic acid. It is an inhibitor of the GLT-1 glutamate transporter.^[1]

References

↑ Kawahara, K; Hosoya, R; Sato, H; Tanaka, M; Nakajima, T; Iwabuchi, S (2002). "Selective blockade of astrocytic glutamate transporter GLT-1 with dihydrokainate prevents neuronal death during ouabain treatment of astrocyte/neuron cocultures". Glia. 40 (3): 337–49. doi:10.1002/glia.10133. PMID 12420313.

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