Hydroxycyclohexanecarboxylate dehydrogenase

In enzymology, a hydroxycyclohexanecarboxylate dehydrogenase (EC 1.1.1.166) is an enzyme that catalyzes the chemical reaction

(1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate + NAD⁺ (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate + NADH + H⁺

Thus, the two substrates of this enzyme are (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate and NAD⁺, whereas its 3 products are (1S,4S)-4-hydroxy-3-oxocyclohexane-1-carboxylate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (1S,3R,4S)-3,4-dihydroxycyclohexane-1-carboxylate:NAD⁺ 3-oxidoreductase. Other names in common use include dihydroxycyclohexanecarboxylate dehydrogenase, and (−)t-3,t-4-dihydroxycyclohexane-c-1-carboxylate-NAD⁺ oxidoreductase.

References

• Whiting GC, Coggins RA (1974). "A new nicotinamide–adenine dinucleotide-dependent hydroaromatic dehydrogenase of Lactobacillus plantarum and its role in formation of (−)t-3t-4-dihydroxycyclohexane-c-1-carboxylate". Biochem. J. 141 (1): 35–42. PMC 1168046. PMID 4375976.