Phosphoglucosamine mutase

In enzymology, a phosphoglucosamine mutase (EC 5.4.2.10) is an enzyme that catalyzes the chemical reaction

alpha-D-glucosamine 1-phosphate D-glucosamine 6-phosphate

Hence, this enzyme has one substrate, alpha-D-glucosamine 1-phosphate, and one product, D-glucosamine 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-glucosamine 1,6-phosphomutase. This enzyme participates in aminosugars metabolism.

References

• Mengin-Lecreulx D, van Heijenoort J (1996). "Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli". J. Biol. Chem. 271 (1): 32–9. doi:10.1074/jbc.271.1.32. PMID 8550580. 
• De Reuse H, Labigne A, Mengin-Lecreulx D (1997). "The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase". J. Bacteriol. 179 (11): 3488–93. PMC 179139. PMID 9171391. 
• Tomasz A; Wu, S; Van Heijenoort, J; De Lencastre, H; Mengin-Lecreulx, D; Tomasz, A (1997). "The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase". J. Bacteriol. 179 (17): 5321–5. PMC 179399. PMID 9286983. 
• Mengin-Lecreulx D; Ferrari, P; Blanot, D; Van Heijenoort, J; Fassy, F; Mengin-Lecreulx, D (1999). "Reaction mechanism of phosphoglucosamine mutase from Escherichia coli". Eur. J. Biochem. 262 (1): 202–10. doi:10.1046/j.1432-1327.1999.00373.x. PMID 10231382. 
• Jolly L, Pompeo F, van Heijenoort J, Fassy F, Mengin-Lecreulx D (2000). "Autophosphorylation of phosphoglucosamine mutase from Escherichia coli". J. Bacteriol. 182 (5): 1280–5. doi:10.1128/JB.182.5.1280-1285.2000. PMC 94413. PMID 10671448.