S-alkylcysteine lyase

In enzymology, a S-alkylcysteine lyase (EC 4.4.1.6) is an enzyme that catalyzes the chemical reaction

an S-alkyl-L-cysteine + water an alkyl thiol + ammonia + pyruvate

Thus, the two substrates of this enzyme are S-alkyl-L-cysteine and water, whereas its three products are alkyl thiol, ammonia, and pyruvate.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is S-alkyl-L-cysteine alkyl-thiol-lyase (deaminating; pyruvate-forming). Other names in common use include S-alkylcysteinase, alkylcysteine lyase, S-alkyl-L-cysteine sulfoxide lyase, S-alkyl-L-cysteine lyase, S-alkyl-L-cysteinase, alkyl cysteine lyase, and S-alkyl-L-cysteine alkylthiol-lyase (deaminating). It employs one cofactor, pyridoxal phosphate.

References

• Nomura J, Nishizuka Y, Hayaishi O (1963). "S-Alkylcysteinase: enzymatic cleavage of S-methyl-L-cysteine and its sulfoxide". J. Biol. Chem. 238: 1441–1446.