Sabarubicin

Sabarubicin
Clinical data

ATC code	none
Identifiers
PubChem (CID)	151897
ChemSpider	133880
UNII	XS499WOZ93^Y
ChEMBL	CHEMBL591251
Chemical and physical data
Formula	C₃₂H₃₇NO₁₃
Molar mass	643.64 g/mol
3D model (Jmol)	Interactive image
SMILES C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@@H]2[C@@H](O[C@H](C[C@@H]2O)O[C@H]3C[C@@](Cc4c3c(c5c(c4O)C(=O)c6ccccc6C5=O)O)(C(=O)CO)O)C)N)O
InChI InChI=InChI=1S/C32H37NO13/c1-12-26(37)17(33)7-21(43-12)46-31-13(2)44-22(8-18(31)35)45-19-10-32(42,20(36)11-34)9-16-23(19)30(41)25-24(29(16)40)27(38)14-5-3-4-6-15(14)28(25)39/h3-6,12-13,17-19,21-22,26,31,34-35,37,40-42H,7-11,33H2,1-2H3/t12-,13-,17-,18-,19-,21-,22-,26+,31-,32-/m0/s1

Sabarubicin (MEN-10755), a disaccharide analog of doxorubicin, is used for the treatment of small cell lung cancer (SCLC).^[1] It has been seen to show superior antitumour efficacy, which is purported to be linked to the activation of p53-independent apoptosis.^[2]

References

This article is issued from Wikipedia - version of the 1/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.