Bephenium hydroxynaphthoate

Bephenium hydroxynaphthoate
Clinical data

Pregnancy category	Undefined
Routes of administration	Oral
ATC code	P02CX02 (WHO)
Pharmacokinetic data
Bioavailability	<1%
Excretion	Renal (negligible)
Identifiers
IUPAC name N-benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxynaphthalene-2-carboxylate
CAS Number	7181-73-9^N 3818-50-6 (hydroxynaphtoate)
PubChem (CID)	19667
ChemSpider	18524^Y
UNII	47RU9546DX^N
ChEMBL	CHEMBL1673148^N
Chemical and physical data
Formula	C₁₇H₂₂NO⁺
Molar mass	256.36 g/mol
3D model (Jmol)	Interactive image
SMILES O(c1ccccc1)CC[N+](Cc2ccccc2)(C)C
InChI InChI=1S/C17H22NO/c1-18(2,15-16-9-5-3-6-10-16)13-14-19-17-11-7-4-8-12-17/h3-12H,13-15H2,1-2H3/q+1^N Key:AVWWVJUMXRXPNF-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

Bephenium hydroxynaphthoate (INN, trade names Alcopara, Alcopar, Befenium, Debefenium, Francin, Nemex) is an anthelmintic agent formerly used in the treatment of hookworm infections and ascariasis.^[1]^[2]

Bephenium is not FDA-approved and is not available in the United States.^[3]

References

↑ Sweetman S, ed. (2009). Martindale: The complete drug reference (36th ed.). London: Pharmaceutical Press. p. 143. ISBN 978-0-85369-840-1.
↑ Jayewardene G, Ismail MM, Wijayaratnam Y (July 1960). "Bephenium hydroxynaphthoate in treatment of ascariasis". Br Med J. 2 (5194): 268–71. doi:10.1136/bmj.2.5194.268. PMC 2097409. PMID 14406934.
↑ Pham PA (March 19, 2009). "Bephenium hydroxynaphthoate". Point-of-Care Information Technology ABX Guide. Johns Hopkins University. Retrieved on March 25, 2011.

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

This article is issued from Wikipedia - version of the 5/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.