Epsiprantel

Epsiprantel
Clinical data

Trade names	Cestex
Routes of administration	By mouth (tablets)
ATCvet code	QP52AA04 (WHO)
Legal status
Legal status	US: ℞-only
Pharmacokinetic data
Bioavailability	Minimal^[1]
Identifiers
IUPAC name 2-(Cyclohexylcarbonyl)-2,3,6,7,8,12b-hexahydropyrazino[2,1-a][2]benzazepin-4(1H)-one
Synonyms	BRL 38705
CAS Number	98123-83-2
PubChem (CID)	72026
ChemSpider	65020
ChEMBL	CHEMBL64979
Chemical and physical data
Formula	C₂₀H₂₆N₂O₂
Molar mass	326.433 g/mol
3D model (Jmol)	Interactive image
SMILES O=C4N2C(c1c(cccc1)CCC2)CN(C(=O)C3CCCCC3)C4
InChI InChI=1S/C20H26N2O2/c23-19-14-21(20(24)16-8-2-1-3-9-16)13-18-17-11-5-4-7-15(17)10-6-12-22(18)19/h4-5,7,11,16,18H,1-3,6,8-10,12-14H2 Key:LGUDKOQUWIHXOV-UHFFFAOYSA-N

Epsiprantel (trade name Cestex) is a veterinary drug which is used as an anthelmintic against tapeworms such as Echinococcus granulosus.^[2]

Indications

It is indicated for the removal of cestodes (tapeworms) in cats (Dipylidium caninum and Taenia taeniaeformis) and dogs (Dipylidium caninum and Taenia pisiformis) 7 weeks of age and older.^[1]

1 2 "Cestex (epsiprantel) Veterinary Tablets. Prescribing Information" (PDF). Zoetis Inc. Kalamazoo, MI 49007. Retrieved 2 October 2016.
↑ Arru, E.; Garippa, G.; Manger, B. R. (1990). "Efficacy of epsiprantel against Echinococcus granulosus infections in dogs". Research in Veterinary Science. 49 (3): 378–379. PMID 2267429.

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel Morantel Carbantel Febantel (aka felsantel)

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

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