Lumefantrine
 | |
| Clinical data | |
|---|---|
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a609024 |
| Routes of administration | Oral |
| ATC code | P01BF01 (WHO) (combination with artemether) |
| Legal status | |
| Legal status |
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| Identifiers | |
| |
| CAS Number |
82186-77-4  |
| PubChem (CID) | 6437380 |
| DrugBank |
DB06708  |
| ChemSpider |
4941944 |
| UNII |
F38R0JR742 |
| KEGG |
D03821 |
| ChEBI |
CHEBI:156095 |
| ChEMBL |
CHEMBL38827 |
| ECHA InfoCard | 100.133.797 |
| Chemical and physical data | |
| Formula | C30H32Cl3NO |
| Molar mass | 528.939 g/mol |
| 3D model (Jmol) | Interactive image |
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| (what is this?) (verify) | |
Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.[1] Lumefantrine has a much longer half-life compared to artemether and so is therefore thought to clear any residual parasites that remain after combination treatment.[2]
Lumefantrine, along with pyronaridine and naphtoquine, were synthesized in course of the Project 523 antimalaria drug research initiated in 1967; these compounds are all used in combination antimalaria therapies.[3][4][5]
See also
References
- ↑ Toovey S, Jamieson A, Nettleton G (2003). "Successful co-artemether (artemether-lumefantrine) clearance of falciparum malaria in a patient with severe cholera in Mozambique". Travel medicine and infectious disease. 1 (3): 177–9. doi:10.1016/j.tmaid.2003.09.002. PMID 17291911.
- ↑ White, Nicholas J.; van Vugt, Michele; Ezzet, Farkad (1999). "Clinical Pharmacokinetics and Pharmacodynamics of Artemether-Lumefantrine". Clinical Pharmacokinetics. 37 (2): 105–125. doi:10.2165/00003088-199937020-00002. ISSN 0312-5963.
- ↑ Cui, Liwang; Su, Xin-zhuan (2009). "Discovery, mechanisms of action and combination therapy of artemisinin". Expert Review of Anti-infective Therapy. 7 (8): 999–1013. doi:10.1586/eri.09.68. PMC 2778258
. PMID 19803708. - ↑ http://aac.asm.org/content/56/5/2465.full
- ↑ Laman, M; Moore, BR; Benjamin, JM; Yadi, G; Bona, C; Warrel, J; Kattenberg, JH; Koleala, T; Manning, L; Kasian, B; Robinson, LJ; Sambale, N; Lorry, L; Karl, S; Davis, WA; Rosanas-Urgell, A; Mueller, I; Siba, PM; Betuela, I; Davis, TM (2014). "Artemisinin-naphthoquine versus artemether-lumefantrine for uncomplicated malaria in Papua New Guinean children: an open-label randomized trial". PLoS Med. 11: e1001773. doi:10.1371/journal.pmed.1001773. PMC 4280121. PMID 25549086.
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