Phenylethylidenehydrazine
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| Clinical data | |
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| ATC code | none |
| Legal status | |
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| Pharmacokinetic data | |
| Biological half-life | ~12 hours |
| Identifiers | |
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| CAS Number | 29443-41-2 |
| PubChem (CID) | 10103216 |
| ChemSpider | 8278744 |
| Chemical and physical data | |
| Formula | C8H10N2 |
| Molar mass | 134.18 g/mol |
| 3D model (Jmol) | Interactive image |
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Phenylethylidenehydrazine (PEH), also known as 2-phenylethylhydrazone or β-phenylethylidenehydrazine, is an inhibitor of the enzyme GABA transaminase (GABA-T).[1][2] It is a metabolite of the antidepressant phenelzine and is responsible for its elevation of GABA concentrations.[1] PEH may contribute to phenelzine's anxiolytic effects.
See also
References
- 1 2 Parent MB, Master S, Kashlub S, Baker GB (January 2002). "Effects of the antidepressant/antipanic drug phenelzine and its putative metabolite phenylethylidenehydrazine on extracellular gamma-aminobutyric acid levels in the striatum". Biochemical Pharmacology. 63 (1): 57–64. doi:10.1016/S0006-2952(01)00856-5. PMID 11754874.
- ↑ Duffy S, Nguyen PV, Baker GB (2004). "Phenylethylidenehydrazine, a novel GABA-transaminase inhibitor, reduces epileptiform activity in rat hippocampal slices". Neuroscience. 126 (2): 423–32. doi:10.1016/j.neuroscience.2004.03.007. PMID 15207360.
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