Acolbifene
 | |
| Names | |
|---|---|
| IUPAC name
(2S)-3-(4-Hydroxyphenyl)-4-methyl-2-[4-(2-piperidin-1-ylethoxy)phenyl]-2H-chromen-7-ol | |
| Other names
EM-652 | |
| Identifiers | |
| 252555-01-4 | |
| 3D model (Jmol) | Interactive image |
| ChEMBL | ChEMBL68055 |
| ChemSpider | 136930 |
| PubChem | 155435 |
| |
| |
| Properties | |
| C29H31NO4 | |
| Molar mass | 457.57 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Acolbifene (INN) (developmental code names EM-652, SCH 57068) is a selective estrogen receptor modulator that, as of 2015, is in phase III clinical trials for the treatment of breast cancer.[1]
References
- ↑ Gauthier, S; Cloutier, J; Dory, YL; Favre, A; Mailhot, J; Ouellet, C; Schwerdtfeger, A; Mérand, Y; Martel, C; Simard, J; Labrie, F (2005). "Synthesis and structure-activity relationships of analogs of EM-652 (acolbifene), a pure selective estrogen receptor modulator. Study of nitrogen substitution". Journal of enzyme inhibition and medicinal chemistry. 20 (2): 165–77. doi:10.1080/14756360500043448. PMID 15968821.
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