Diacylglycerol lipase
| diacylglycerol lipase, alpha | |
|---|---|
| Identifiers | |
| Symbol | DAGLA |
| Alt. symbols | C11orf11 |
| Entrez | 747 |
| HUGO | 1165 |
| RefSeq | NM_006133 |
| UniProt | Q9Y4D2 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 11 q12.3 |
| diacylglycerol lipase, beta | |
|---|---|
| Identifiers | |
| Symbol | DAGLB |
| Entrez | 221955 |
| HUGO | 28923 |
| RefSeq | NM_139179 |
| UniProt | Q8NCG7 |
| Other data | |
| EC number | 3.1.1.- |
| Locus | Chr. 7 p22.1 |
Diacylglycerol lipase, also known as DAG lipase, DAGL or DGL, is a key enzyme in the biosynthesis of the endocannabinoid 2-arachidonoylglycerol.[1] It catalyzes the hydrolysis of diacylglycerol, releasing a free fatty acid and monoacylglycerol.
Two separate genes encoding DGL enzymes have been cloned, termed DGLα (DAGLA) and DGLβ (DAGLB), that share 33% sequence identity.
Inhibitors
The enzyme has been described to be inhibited selectively by two agents, RHC80267 and tetrahydrolipstatin.
References
- ↑ Bisogno T, Howell F, Williams G, et al. (November 2003). "Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain". J. Cell Biol. 163 (3): 463–8. doi:10.1083/jcb.200305129. PMC 2173631
. PMID 14610053.
External links
- Diacylglycerol Lipase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 3.1.1.34
| Activity | |
|---|---|
| Regulation | |
| Classification | |
| Types |
|
| Precursor | |
|---|---|
| Prostanoids | |
| Leukotrienes | |
| Ungrouped | |
| Receptor (ligands) |
| ||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Enzyme (inhibitors) |
| ||||||||||||||||||||||||||||||||||||||||||||||
| Others | |||||||||||||||||||||||||||||||||||||||||||||||
See also: Leukotrienergics | |||||||||||||||||||||||||||||||||||||||||||||||
| Receptor (ligands) |
| ||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Enzyme (inhibitors) |
| ||||||||||||||||||||||||||||||
| Others | |||||||||||||||||||||||||||||||
See also: Prostanoids | |||||||||||||||||||||||||||||||
This article is issued from Wikipedia - version of the 5/19/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.