Antrafenine
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| Clinical data | |
|---|---|
| Routes of administration | Oral |
| ATC code | none |
| Legal status | |
| Legal status |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal |
| Identifiers | |
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| CAS Number |
55300-30-6  Y |
| PubChem (CID) | 68723 |
| DrugBank |
DB01419 Y |
| ChemSpider |
61973 Y |
| UNII |
21FS93Y6OE Y |
| ChEMBL |
CHEMBL345524 Y |
| Chemical and physical data | |
| Formula | C30H26F6N4O2 |
| Molar mass | 588.543 g/mol |
| 3D model (Jmol) | Interactive image |
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| (verify) | |
Antrafenine (Stakane) is a phenylpiperazine derivative drug invented in 1979.[1] It acts as an analgesic and anti-inflammatory drug with similar efficacy to naproxen,[2] but is not widely used as it has largely been replaced by newer drugs.
See also
References
- ↑ Manoury PM, Dumas AP, Najer H, Branceni D, Prouteau M, Lefevre-Borg FM. Synthesis and analgesic activities of some (4-substituted phenyl-1-piperazinyl)alkyl 2-aminobenzoates and 2-aminonicotinates. Journal of Medicinal Chemistry. 1979 May;22(5):554-9.
- ↑ Leatham PA, Bird HA, Wright V, Seymour D, Gordon A. A double blind study of antrafenine, naproxen and placebo in osteoarthrosis. European Journal of Rheumatology and Inflammation. 1983;6(2):209-11.
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| N-Arylanthranilic acids (fenamates) | |
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Items listed in bold indicate initially developed compounds of specific groups. #WHO-EM †Withdrawn drugs. ‡Veterinary use medications. | |
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| Simple piperazines (no additional rings) | |
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| Phenylpiperazines |
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| Diphenylalkylpiperazines (benzhydrylalkylpiperazines) |
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